Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | GRB2 | P62993 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650871 | 0.94 | PTPN1 (0.62) | PTPN1ITGB3ITGA2BALDH1A1MAPK1 | |
| SCHEMBL4651374 | 0.92 | PTPN1 (0.56) | PTPN1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4651102 | 0.90 | PTPN1 (0.61) | PTPN1ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4650251 | 0.90 | PTPN1 (0.62) | PTPN1ALDH1A1MAPTSMN1; SMN2TBXA2R | |
| SCHEMBL4650882 | 0.90 | PTPN1 (0.69) | PTPN1 | |
| SCHEMBL4650268 | 0.88 | PTPN1 (0.58) | PTPN1TBXA2RTBXAS1GRB2 | |
| SCHEMBL4650968 | 0.88 | PTPN1 (0.62) | PTPN1TBXA2RTBXAS1GRB2 | |
| SCHEMBL4651106 | 0.87 | PTPN1 (0.51) | PTPN1GRB2 | |
| SCHEMBL4651215 | 0.85 | PTPN1 (0.60) | PTPN1ALDH1A1TBXA2RTBXAS1 | |
| SCHEMBL4651320 | 0.85 | PTPN1 (0.60) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539115-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | claimed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | claimed |
| US-6410585-B1 | THERAPY FOR NON-INSULIN DEPEND DIABETES | BIOVITRUM AB (SE) | 2002-06-25 | — | — | US | disclosed |
| EP-1161421-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | Pharmacia & Upjohn Aktiebolag (SE) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000053583-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE | BIOVITRUM AB (SE) | 2000-09-14 | — | — | WO | disclosed |