Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 16/20 | 0.60 |
| ▸ | FNTB | P49356 | 16/20 | 0.60 |
| ▸ | PGGT1B | P53609 | 15/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970458 | 0.76 | FNTA (0.60) | FNTAFNTBPGGT1B | |
| SCHEMBL7676910 | 0.76 | FNTA (0.91) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL3502107 | 0.76 | FNTA (0.59) | FNTAFNTBPGGT1B | |
| SCHEMBL7676151 | 0.75 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL7674263 | 0.74 | FNTA (0.75) | FNTAFNTBPGGT1B | |
| SCHEMBL3501631 | 0.73 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL29473350 | 0.73 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL3500640 | 0.72 | FNTA (0.58) | FNTAFNTBPGGT1B | |
| SCHEMBL7674157 | 0.72 | FNTA (0.88) | FNTAFNTBPGGT1B | |
| SCHEMBL7671181 | 0.72 | FNTA (0.92) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020037888-A1 | 4-imidazol-1-ylmethyl-2-(2-(2-oxo-piperidin-1-yl)-phenoxy) -benzonitrile for example; farnesyl-protein transferase inhibitors; treating cancer, benign proliferative disorder, hepatitis virus, restenosis, and polycystic kidney disease | MERCK & CO., INC. | 2002-03-28 | — | — | US | claimed |
| EP-0981556-A1 | ETHYLENE/ALPHA-OLEFIN/DIENE INTERPOLYMERS AND THEIR PREPARATION | THE DOW CHEMICAL COMPANY (US) | 2000-03-01 | — | — | EP | claimed |
| WO-1998049212-A1 | ETHYLENE/ALPHA-OLEFIN/DIENE INTERPOLYMERS AND THEIR PREPARATION | THE DOW CHEMICAL COMPANY (US) | 1998-11-05 | — | — | WO | claimed |
| US-20020037888-A1 | 4-imidazol-1-ylmethyl-2-(2-(2-oxo-piperidin-1-yl)-phenoxy) -benzonitrile for example; farnesyl-protein transferase inhibitors; treating cancer, benign proliferative disorder, hepatitis virus, restenosis, and polycystic kidney disease | MERCK & CO., INC. | 2002-03-28 | — | — | US | disclosed |
| US-6284755-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-09-04 | — | — | US | disclosed |
| WO-2000034437-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037888-A1 | 4-imidazol-1-ylmethyl-2-(2-(2-oxo-piperidin-1-yl)-phenoxy) -benzonitrile for example; farnesyl-protein transferase inhibitors; treating cancer, benign proliferative disorder, hepatitis virus, restenosis, and polycystic kidney disease | FNTA, PKD1, FNTB | FNTA 1/4885FNTB 3/4885PGGT1B 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.