Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | SNCA | P37840 | 4/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679164 | 1.00 | MAPT (0.50) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7670343 | 0.77 | APP (0.47) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7670335 | 0.77 | APP (0.47) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL803139 | 0.77 | KMT2A (0.50) | MAPTHCRTR1PDE10AKDM4EALDH1A1 | |
| SCHEMBL29158518 | 0.75 | MAPT (0.66) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7677880 | 0.74 | APP (0.58) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7677885 | 0.74 | APP (0.58) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7678890 | 0.72 | APP (0.75) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7678889 | 0.72 | APP (0.75) | MAPTAPPSNCAHCRTR1ITGA4 | |
| SCHEMBL7676181 | 0.71 | APP (0.57) | MAPTAPPSNCAHCRTR1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | MAPT 2381/4885APP 4305/4885SNCA 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.