Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680478 | 0.92 | KDR (0.51) | KDRFGFR1PDGFRBCHEK1 | |
| SCHEMBL7676095 | 0.90 | KDR (0.49) | KDRFGFR1PDGFRBCHEK1 | |
| SCHEMBL7679697 | 0.84 | KDR (0.56) | KDRFGFR1PDGFRB | |
| SCHEMBL5082076 | 0.84 | CHEK1 (0.66) | KDRCHEK1 | |
| SCHEMBL7677131 | 0.82 | KDR (0.53) | KDRFGFR1PDGFRBCHEK1 | |
| SCHEMBL7679244 | 0.80 | CHEK1 (0.53) | KDRFGFR1PDGFRBCHEK1 | |
| Methane SCHEMBL7681400 | 0.77 | KDR (0.51) | KDRFGFR1PDGFRBCHEK1 | |
| Methane SCHEMBL7673830 | 0.76 | KDR (0.49) | KDRFGFR1PDGFRBCHEK1 | |
| SCHEMBL148591 | 0.76 | CHEK1 (0.55) | KDRCHEK1 | |
| SCHEMBL7673836 | 0.75 | KDR (0.51) | KDRFGFR1PDGFRBCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479512-B1 | TO TREAT TYROSINE KINASE-DEPENDENT DISEASES AND CONDITIONS, SUCH AS ANGIOGENESIS, CANCER, TUMOR GROWTH, ATHEROSCLEROSIS, AGE RELATED MACULAR DEGENERATION, DIABETIC RETINOPATHY, INFLAMMATORY DISEASES, ETC. | MERCK & CO., INC. | 2002-11-12 | — | — | US | disclosed |