Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368357 | 1.00 | MEN1 (0.43) | MEN1KMT2AMAPK8AURKALCK | |
| SCHEMBL7370609 | 0.86 | MEN1 (0.44) | MEN1KMT2AMAPK8AURKALCK | |
| SCHEMBL7371026 | 0.84 | POLB (0.47) | MEN1KMT2AMAPK8AURKALCK | |
| SCHEMBL7368438 | 0.82 | POLB (0.53) | AURKALCKMETKDRTEK | |
| SCHEMBL7371576 | 0.82 | PDE4A (0.59) | MAPK8AURKALCKMETKDR | |
| SCHEMBL7371736 | 0.82 | PDE4A (0.43) | AURKALCKMETKDRTEK | |
| SCHEMBL7374630 | 0.77 | MAPK8 (0.58) | KMT2AMAPK8 | |
| SCHEMBL7365059 | 0.77 | MAPK8 (0.58) | KMT2AMAPK8 | |
| SCHEMBL7365065 | 0.77 | MAPK8 (0.58) | KMT2AMAPK8 | |
| SCHEMBL7364476 | 0.77 | PARP10 (0.48) | KMT2AMAPK8AURKALCKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |