Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.83 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.83 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.83 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088575 | 1.00 | HMGCR (0.83) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628292 | 0.91 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628298 | 0.91 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628294 | 0.91 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL1265 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL12060138 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL13762456 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL10025147 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL12648491 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 | |
| Atorvastatin Lactone SCHEMBL1266 | 0.91 | HMGCR (1.00) | HMGCRABCB1ABCC2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355810-B1 | TREATMENT AND PREVENTION OF HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA, ATHEROSCLEROSIS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| EP-1083894-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063994-A9 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999063994-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
| US-4775681-A | Method of treating fungal infections with trans-6-[2-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones | WARNER-LAMBERT COMPANY (US) | 1988-10-04 | — | — | US | disclosed |
| US-4647576-A | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0179559-A2 | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |