Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 5/20 | 0.40 |
| ▸ | ACACA | Q13085 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246825 | 1.00 | BTK (0.61) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL5262829 | 1.00 | BTK (0.61) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL8141945 | 1.00 | BTK (0.61) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL4354977 | 0.91 | KMT2A (0.60) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL4346477 | 0.91 | KMT2A (0.60) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL6641586 | 0.91 | KMT2A (0.60) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL6641585 | 0.91 | KMT2A (0.60) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL25036375 | 0.89 | KMT2A (0.64) | BTKKMT2ASMN1; SMN2EPHX1CTSS | |
| SCHEMBL6647123 | 0.88 | EPHX1 (0.48) | BTKKMT2AEPHX1CTSSCTSK | |
| SCHEMBL5507221 | 0.87 | BTK (0.46) | BTKKMT2ASMN1; SMN2EPHX1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489327-B1 | TREATING A DISEASE SUSCEPTIBLE TO TRYPTASE INHIBITION SUCH AS ASTHMA, INFLAMMATORY BOWEL DISEASE, PSORIASIS OR RHINITIS | MAX-PLANCK-GESELLSCHAFT ZUR FORDRUNGDER WISENSCHAFTEN, E.V. (DE) | 2002-12-03 | — | — | US | disclosed |