Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 20/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547903 | 1.00 | TACR1 (0.45) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL7550074 | 1.00 | TACR1 (0.45) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL4691572 | 0.92 | TACR1 (0.45) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL6355420 | 0.90 | TACR1 (0.44) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL7550666 | 0.90 | TACR1 (0.44) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL7553900 | 0.90 | TACR1 (0.44) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL6615409 | 0.90 | TACR1 (0.56) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL5412788 | 0.90 | TACR1 (0.56) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL4693187 | 0.90 | TACR1 (0.56) | TACR1NR3C1CYP3A4FPR1TACR3 | |
| SCHEMBL5412707 | 0.90 | TACR1 (0.56) | TACR1NR3C1CYP3A4FPR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489343-B2 | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 2002-12-03 | — | — | US | disclosed |