Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NDUFS8 | O00217 | 1/20 | 0.35 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.35 |
| ▸ | NDUFAB1 | O14561 | 1/20 | 0.35 |
| ▸ | NDUFA1 | O15239 | 1/20 | 0.35 |
| ▸ | NDUFS4 | O43181 | 1/20 | 0.35 |
| ▸ | NDUFB5 | O43674 | 1/20 | 0.35 |
| ▸ | NDUFB3 | O43676 | 1/20 | 0.35 |
| ▸ | NDUFC1 | O43677 | 1/20 | 0.35 |
| ▸ | NDUFA2 | O43678 | 1/20 | 0.35 |
| ▸ | NDUFS5 | O43920 | 1/20 | 0.35 |
| ▸ | NDUFS7 | O75251 | 1/20 | 0.35 |
| ▸ | NDUFS2 | O75306 | 1/20 | 0.35 |
| ▸ | NDUFS6 | O75380 | 1/20 | 0.35 |
| ▸ | NDUFB1 | O75438 | 1/20 | 0.35 |
| ▸ | NDUFS3 | O75489 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7683085 | 1.00 | LSS (0.48) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7687862 | 0.87 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7687868 | 0.87 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7683408 | 0.85 | LSS (0.56) | LSSMEN1KMT2AMAOBMAOA | |
| SCHEMBL7683401 | 0.85 | LSS (0.56) | LSSMEN1KMT2AMAOBMAOA | |
| SCHEMBL7681960 | 0.85 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7681964 | 0.85 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7681955 | 0.85 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL7768122 | 0.85 | LSS (0.47) | LSSMEN1KMT2AMAOBKDM4E | |
| SCHEMBL3684952 | 0.83 | LSS (0.62) | LSSMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |
| EP-0778271-A2 | Aminoalkyl-substituted benzo-heterocyclic compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |