Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 4/20 | 0.43 |
| ▸ | FNTB | P49356 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618635 | 1.00 | NR1H2 (0.44) | NR1H2NR1H3FNTAFNTBMEN1 | |
| SCHEMBL6634181 | 0.86 | FNTA (0.49) | NR1H2NR1H3FNTAFNTBMEN1 | |
| SCHEMBL6619143 | 0.86 | FNTA (0.49) | NR1H2NR1H3FNTAFNTBMEN1 | |
| SCHEMBL6632636 | 0.86 | FNTA (0.56) | FNTAFNTB | |
| SCHEMBL6615857 | 0.83 | FNTA (0.45) | FNTAFNTBMEN1KMT2ADPP4 | |
| SCHEMBL6618500 | 0.83 | NR1H2 (0.39) | NR1H2NR1H3MEN1KMT2AHDAC8 | |
| SCHEMBL6627228 | 0.83 | FNTA (0.44) | FNTAFNTBMEN1KMT2AMAPK1 | |
| SCHEMBL6614346 | 0.82 | NR1H2 (0.44) | NR1H2NR1H3MEN1KMT2AHDAC8 | |
| SCHEMBL6630439 | 0.81 | FNTA (0.44) | FNTAFNTBMEN1KMT2AMAPK1 | |
| SCHEMBL6618037 | 0.81 | FNTA (0.43) | FNTAFNTBMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455523-B1 | ADMINISTERING 1,4-BENZODIAZEPINE DERIVATIVE AS ANTITUMOR OR ANTICARCINOGENIC AGENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-24 | — | — | US | disclosed |
| US-6011029-A | BENZODIAZEPINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |