SCHEMBL7684418

SCHEMBL7684418

NC(C(=O)O)c1ccc2c(c1)OCO2

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK9 P45984 1/20 0.55
HSD17B10 Q99714 5/20 0.54
KMT2A Q03164 4/20 0.54
CYP2C9 P11712 4/20 0.54
TDP1 Q9NUW8 4/20 0.54
CYP2C19 P33261 3/20 0.54
MEN1 O00255 3/20 0.54
CYP2D6 P10635 2/20 0.54
GRM8 O00222 1/20 0.54
GRM6 O15303 1/20 0.54
SLC6A2 P23975 1/20 0.54
SLC6A4 P31645 1/20 0.54
DRD3 P35462 1/20 0.54
GRM4 Q14833 1/20 0.54
PTGS1 P23219 1/20 0.53
PTGS2 P35354 1/20 0.53
ALDH1A1 P00352 5/20 0.51
MAPK1 P28482 2/20 0.51
EDNRA P25101 1/20 0.49
CYP1A2 P05177 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3619668 0.90 PTGS1 (0.66) MAPK9HSD17B10KMT2ACYP2C9TDP1
SCHEMBL8874548 0.83 MAPK9 (0.52) MAPK9HSD17B10KMT2ACYP2C9CYP2C19
SCHEMBL5281154 0.83 MAPK9 (0.52) MAPK9HSD17B10KMT2ACYP2C9CYP2C19
SCHEMBL11459800 0.82 MAPK9 (0.57) MAPK9HSD17B10KMT2ACYP2C9CYP2C19
SCHEMBL5279500 0.82 PTGS1 (0.55) MAPK9KMT2ACYP2C9TDP1CYP2C19
SCHEMBL7433780 0.82 PTGS1 (0.55) MAPK9KMT2ACYP2C9TDP1CYP2C19
SCHEMBL16208746 0.82 PTGS1 (0.55) MAPK9KMT2ACYP2C9TDP1CYP2C19
SCHEMBL14032401 0.81 EDNRA (0.54) KMT2AMEN1ALDH1A1EDNRACYP3A4
SCHEMBL10204938 0.81 EDNRA (0.54) KMT2AMEN1ALDH1A1EDNRACYP3A4
SCHEMBL4510613 0.81 MAPK9 (0.56) MAPK9HSD17B10KMT2ACYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170172957-A1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS ALLERGAN, INC. 2017-06-22 US disclosed
EP-2714029-B1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS ALLERGAN INC (US) 2017-04-12 EP disclosed
US-8741955-B2 D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders ALLERGAN, INC. (US) 2014-06-03 US disclosed
US-8735451-B2 D-serine transporter inhibitors as pharmaceutical compositions for the treatment of visual system disorders ALLERGAN, INC. (US) 2014-05-27 US disclosed
US-20120329851-A1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS ALLERGAN, INC. 2012-12-27 US disclosed
US-20120302621-A1 D-SERINE TRANSPORTER INHIBITORS AS PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VISUAL SYSTEM DISORDERS ALLERGAN, INC. 2012-11-29 US disclosed
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed
US-3994877-A 6-[α-AMINO-ω-(3,4-METHYLENEDIOXYPHENYL)ACYLAMIDO]PENICILLANIC ACID DERIVATIVES RICHARDSON-MERRELL INC. (US) 1976-11-30 US disclosed