Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | PYGM | P11217 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222204 | 0.89 | CNR2 (0.49) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL7684633 | 0.87 | CNR2 (0.63) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL7504727 | 0.86 | CNR2 (0.56) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL6220589 | 0.85 | CNR2 (0.52) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL6221893 | 0.85 | CYP1A2 (0.44) | CNR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6219592 | 0.85 | CNR2 (0.49) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL6219578 | 0.84 | CNR2 (0.59) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| Acetic Acid SCHEMBL6222398 | 0.84 | CNR2 (0.43) | CNR2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6221207 | 0.83 | CNR2 (0.48) | CNR2PLA2G2AGABRA1GABRG2GABRB3 | |
| SCHEMBL6220738 | 0.82 | CNR2 (0.45) | CNR2PLA2G2APPARGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469021-B1 | ANTAGONISTS OF THE INTESTINAL HORMONE GLUCAGONS-LIKE PEPTIDE 1 (GLP-1) HAVE A 9H-B-CARBOLINE CENTRAL MOTIF, FOR REGULATING THE SECRETION OF INSULIN IN DIABETIC PATIENTS | AGOURON PHARMACEUTICALS, INC. | 2002-10-22 | — | — | US | disclosed |