SCHEMBL7684465

SCHEMBL7684465

CC(=O)N1C(C)CC(O)CC1c1cccnc1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.46
CHRNB2 P17787 1/20 0.46
CHRNA4 P43681 1/20 0.46
RIPK1 Q13546 1/20 0.43
KDM4E B2RXH2 3/20 0.43
CYP3A4 P08684 1/20 0.43
THRB P10828 1/20 0.43
TSHR P16473 1/20 0.43
THPO P40225 1/20 0.43
MEN1 O00255 1/20 0.43
MAPK1 P28482 1/20 0.43
KMT2A Q03164 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
BLM P54132 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7590540 1.00 CHRNA7 (0.46) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL27473681 0.88 CHRNA7 (0.47) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7589470 0.88 CHRNA7 (0.47) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7589466 0.88 CHRNA7 (0.47) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7594374 0.84 CHRNA7 (0.43) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7681930 0.84 CHRNA7 (0.43) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7679889 0.80 CHRNA7 (0.52) CHRNA7CHRNB2CHRNA4KDM4ECYP3A4
SCHEMBL7594257 0.80 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7594252 0.80 CHRNA7 (0.40) CHRNA7CHRNB2CHRNA4RIPK1KDM4E
SCHEMBL7590741 0.79 KDM4E (0.46) CHRNA7CHRNB2CHRNA4RIPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6451789-B1 CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS LES LABORTOIRES SERVIER (FR) 2002-09-17 US disclosed
US-6323222-B1 COGNITION ACTIVATORS, ALZHEIMER*S DISEASE AND ENZYME INHIBITORS ADIR ET COMPAGNIE (FR) 2001-11-27 US disclosed