Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058724 | 0.91 | CCR1 (0.35) | CCR1TSHRMMP1MMP13METAP2 | |
| SCHEMBL27540607 | 0.89 | CCR1 (0.52) | CCR1MMP1MMP13METAP2METAP1 | |
| SCHEMBL27565233 | 0.82 | CCR1 (0.38) | CCR1 | |
| SCHEMBL4058726 | 0.80 | CCR1 (0.50) | CCR1CTRB1 | |
| SCHEMBL4064042 | 0.80 | CCR1 (0.43) | CCR1MMP1MMP13METAP2METAP1 | |
| SCHEMBL6169667 | 0.80 | CCR1 (0.43) | CCR1MMP1MMP13METAP2METAP1 | |
| SCHEMBL6832277 | 0.80 | CCR1 (0.41) | CCR1TSHR | |
| SCHEMBL4064274 | 0.80 | CCR1 (0.41) | CCR1TSHR | |
| SCHEMBL4066973 | 0.79 | HPGD (0.35) | CCR1KDM4E | |
| SCHEMBL2675794 | 0.78 | CCR1 (0.40) | CCR1TSHRMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |