Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.48 |
| ▸ | SQLE | Q14534 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687526 | 1.00 | KMT2A (0.54) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL11586065 | 0.82 | KMT2A (0.58) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL356392 | 0.82 | KMT2A (0.58) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL11584608 | 0.82 | KMT2A (0.58) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| Water SCHEMBL9280359 | 0.80 | KMT2A (0.56) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL1616971 | 0.80 | KMT2A (0.56) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL1617090 | 0.80 | KMT2A (0.56) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL808086 | 0.80 | KMT2A (0.56) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL16359707 | 0.78 | KMT2A (0.54) | KMT2AMEN1CYP3A4ALOX15MAPT | |
| SCHEMBL30560064 | 0.78 | KMT2A (0.54) | KMT2AMEN1CYP3A4ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |