Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.74 |
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 3/20 | 0.55 |
| ▸ | LYN | P07948 | 3/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092916 | 0.89 | MAPK14 (0.82) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091692 | 0.86 | MAPK14 (0.84) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6811590 | 0.85 | MAPK14 (0.71) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4092378 | 0.85 | MAPK14 (1.00) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL4091601 | 0.84 | MAPK14 (0.73) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL5455309 | 0.83 | MAPK14 (0.52) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL5379156 | 0.83 | MAPK14 (0.53) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6261564 | 0.82 | MAPK14 (0.52) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL6611341 | 0.82 | ABL1 (0.56) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL5619149 | 0.81 | MAPK14 (0.78) | MAPK14ABL1RAF1LYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358945-B1 | CYTOKINE, TUMOR NECROSIS FACTOR, AND INTERLEUKIN INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |