Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7689586 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL7701212 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL7703198 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL7697654 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL12370647 | 1.00 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL12370652 | 0.93 | NPC1 (0.50) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL17086749 | 0.87 | NPC1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2HDAC1 | |
| SCHEMBL1641388 | 0.87 | MAPT (0.56) | NPC1RAB9AMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL24962598 | 0.84 | HDAC1 (0.47) | HDAC1SLC6A2SLC6A4KDM4EMAPK1 | |
| SCHEMBL4748690 | 0.84 | NR5A1 (0.51) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002024619-A1 | AMINE COMPOUNDS | BTG INTERNATIONAL LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |