Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134215 | 0.95 | CYP11B1 (0.37) | CYP11B1CYP11B2CDK1CDK2TDP1 | |
| SCHEMBL7133297 | 0.90 | ABCB1 (0.39) | CYP11B1CYP11B2TDP1LTA4HHTR6 | |
| SCHEMBL7129966 | 0.89 | CYP11B1 (0.43) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL7691988 | 0.89 | CYP11B1 (0.41) | CYP11B1CYP11B2CDK1CDK2TDP1 | |
| SCHEMBL7164804 | 0.84 | PDE4A (0.39) | CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL7134212 | 0.84 | CYP11B1 (0.36) | CYP11B1CYP11B2CDK1CDK2TDP1 | |
| SCHEMBL7132423 | 0.83 | TP53 (0.38) | HTR6SMN1; SMN2 | |
| SCHEMBL7126737 | 0.82 | HTR1B (0.37) | — | |
| SCHEMBL7125665 | 0.82 | KCNA3 (0.38) | — | |
| SCHEMBL7127769 | 0.82 | MEN1 (0.34) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420391-B1 | PREVENTION AND/OR TREATMENT OF VARIOUS INFLAMMATORY DISEASES, SEPSIS, MULTIPLE MYELOMA, PLASMA CELL LEUKEMIA, OSTEOPOROSIS, CACHEXIA, PSORIASIS, NEPHRITIS, RENAL CELL CARCINOMA, KAPOSI'S SARCOMA, RHEUMATOID ARTHRITIS, GAMMOPATHY, CASTLEMAN'S | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1067128-A1 | FUSED THIOPHENE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-10 | — | — | EP | claimed |