Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396793 | 1.00 | HTT (0.58) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL8394588 | 1.00 | HTT (0.58) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL8391321 | 0.98 | HTT (0.60) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL8395941 | 0.98 | HTT (0.60) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL1474054 | 0.98 | HTT (0.60) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL8393260 | 0.98 | HTT (0.60) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL8397091 | 0.96 | HTT (0.62) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL1681188 | 0.93 | HTT (0.67) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL21902726 | 0.91 | HTT (0.52) | HTTNAMPTTDP1L3MBTL1MEN1 | |
| SCHEMBL24176160 | 0.91 | TDP1 (0.65) | HTTNAMPTTDP1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002006229-A2 | HETEROCYCLIC BETA-3 ADRENERGIC RECEPTOR AGONISTS | WYETH (US) | 2002-01-24 | — | — | WO | disclosed |
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |