Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672350 | 0.85 | GSK3B (0.51) | PIK3CAPIK3CBPIK3CGGSK3BAGPAT2 | |
| SCHEMBL7084492 | 0.79 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGGSK3BAGPAT2 | |
| SCHEMBL5076249 | 0.77 | GSK3B (0.62) | PIK3CAPIK3CBPIK3CGGSK3BNPBWR1 | |
| SCHEMBL4670339 | 0.76 | PIK3CA (0.44) | PIK3CAPIK3CBPIK3CGGSK3BAGPAT2 | |
| SCHEMBL4670338 | 0.76 | GSK3B (0.46) | PIK3CAPIK3CBPIK3CGGSK3BNPBWR1 | |
| SCHEMBL7084499 | 0.76 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGCRHR1GSK3B | |
| SCHEMBL4675036 | 0.75 | GSK3B (0.51) | PIK3CAPIK3CBPIK3CGCRHR1GSK3B | |
| SCHEMBL4670341 | 0.74 | GSK3B (0.63) | PIK3CAPIK3CBPIK3CGCRHR1GSK3B | |
| SCHEMBL7700241 | 0.73 | S1PR4 (0.42) | PIK3CAPIK3CBPIK3CGCRHR1GSK3B | |
| SCHEMBL4675353 | 0.72 | GSK3B (0.50) | PIK3CAPIK3CBPIK3CGCRHR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001044206-A9 | PYRAZINE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORP (US) | 2002-05-23 | — | — | WO | disclosed |