Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696148 | 0.80 | CACNA2D1 (0.46) | CACNA2D1FGFR1KDREGFRFGFR2 | |
| SCHEMBL7696545 | 0.77 | TSHR (0.45) | CACNA2D1FGFR1KDREGFRFGFR2 | |
| SCHEMBL7695093 | 0.72 | CYP1A2 (0.46) | SRCTP53USP2ALDH1A1CYP1A2 | |
| SCHEMBL2326504 | 0.69 | TP53 (0.52) | CACNA2D1FGFR1KDRPOLBTP53 | |
| SCHEMBL10371119 | 0.68 | ADORA1 (0.50) | ADORA1ALDH1A1GLAGAAMERTK | |
| SCHEMBL10367538 | 0.68 | ADORA1 (0.50) | ADORA1ALDH1A1GLAGAAMERTK | |
| SCHEMBL8288058 | 0.64 | CACNA2D1 (1.00) | CACNA2D1POLBGAA | |
| SCHEMBL4259413 | 0.64 | MERTK (0.55) | FGFR1EGFRFGFR2FGFR4FGFR3 | |
| SCHEMBL12120391 | 0.64 | CACNA2D1 (0.68) | CACNA2D1POLBALDH1A1GAA | |
| SCHEMBL14569051 | 0.64 | FGFR1 (0.57) | FGFR1KDREGFRFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076985-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |