Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.72 |
| ▸ | FPR2 | P25090 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823060 | 0.92 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL2279379 | 0.87 | HRH1 (0.57) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8203884 | 0.87 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL8576613 | 0.87 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL7451207 | 0.87 | PDE4A (0.79) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7450822 | 0.86 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL8483493 | 0.86 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8209414 | 0.86 | PDE4A (0.67) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL6798284 | 0.85 | PDE4A (0.65) | PDE4APDE4DPDE4BPDE4CFPR2 | |
| SCHEMBL5818764 | 0.85 | PDE4A (0.76) | PDE4APDE4DPDE4BPDE4CFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002081447-A1 | 3-CYCLOPENTYLOXY-4-METHOXYPHENYL-ISOTHIAZOLINONE DERIVATIVES AND THE USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2002-10-17 | — | — | WO | disclosed |
| WO-2000001387-A1 | FUNGAL GROWTH INHIBITORS | CELGRO, A DIVISION OF CELGENE CORPORATION (US) | 2000-01-13 | — | — | WO | disclosed |
| EP-0745063-B1 | SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | AMERICAN HOME PROD (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5691376-A | ANTIHISTAMINE, ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-25 | — | — | US | disclosed |
| US-5650444-A | BRONCHODILATOR AGENTS, ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-07-22 | — | — | US | disclosed |