Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pidolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pidolic Acid SCHEMBL2355310 | 1.00 | HTR1B (0.54) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Pidolic Acid SCHEMBL8481249 | 0.85 | HTR1B (0.54) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL2303026 | 0.85 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL2302198 | 0.85 | HTR1B (0.61) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL3470109 | 0.84 | HTR1B (0.60) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| Pidolic Acid SCHEMBL9270714 | 0.84 | HTR1B (0.62) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL1875621 | 0.78 | HTR1B (0.52) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL1874947 | 0.78 | HTR1B (0.52) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL1874943 | 0.78 | HTR1B (0.52) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL1875623 | 0.78 | HTR1B (0.52) | HTR1BHTR1AHTR1DDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359146-B1 | RESOLUTION OF ENANTIOMORPH MIXTURE | VERNALIS LIMITED (GB) | 2002-03-19 | — | — | US | disclosed |
| EP-1070051-A1 | PROCESS FOR THE PRODUCTION OF R-(+)-6- CARBOXAMIDO- 3-N- METHYLAMINO- 1,2,3,4- TETRAHYDROCARBAZOLE | Vernalis Limited (GB) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999054302-A1 | PROCESS FOR THE PRODUCTION OF R-(+)-6- CARBOXAMIDO- 3-N- METHYLAMINO- 1,2,3,4- TETRAHYDROCARBAZOLE | VERNALIS LIMITED (GB) | 1999-10-28 | — | — | WO | disclosed |