Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669079 | 0.85 | SMN1; SMN2 (0.57) | MAPK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29407510 | 0.80 | TSHR (0.65) | MAPK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3378134 | 0.80 | TSHR (0.65) | MAPK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7085654 | 0.77 | SMN1; SMN2 (0.59) | MAPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7089468 | 0.77 | SMN1; SMN2 (0.59) | MAPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7085647 | 0.77 | SMN1; SMN2 (0.59) | MAPK1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7698837 | 0.76 | SMN1; SMN2 (0.55) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL7693632 | 0.76 | SMN1; SMN2 (0.55) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7697363 | 0.76 | SMN1; SMN2 (0.55) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL7693636 | 0.76 | SMN1; SMN2 (0.55) | NPC1RAB9AMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495561-B2 | TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE | MERCK & CO., INC. | 2002-12-17 | — | — | US | disclosed |