Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356685 | 1.00 | BACE1 (0.71) | BACE1KCNH2BACE2 | |
| SCHEMBL2468820 | 0.90 | BACE1 (0.69) | BACE1KCNH2BACE2 | |
| Azd-3839 SCHEMBL2465855 | 0.90 | BACE1 (0.90) | BACE1KCNH2BACE2 | |
| SCHEMBL12136046 | 0.87 | BACE1 (0.71) | BACE1KCNH2BACE2 | |
| SCHEMBL7918702 | 0.86 | BACE1 (0.72) | BACE1KCNH2BACE2 | |
| SCHEMBL2465221 | 0.85 | BACE1 (0.58) | BACE1KCNH2BACE2 | |
| SCHEMBL2463250 | 0.84 | BACE1 (0.69) | BACE1KCNH2BACE2 | |
| SCHEMBL2496387 | 0.83 | BACE1 (0.71) | BACE1KCNH2BACE2 | |
| Azd-3839 SCHEMBL12136074 | 0.83 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL12191257 | 0.83 | BACE1 (0.86) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281894-A1 | HEMIFUMARATE SALT | ASTRAZENECA AB (SE) | 2011-11-17 | — | — | US | disclosed |
| US-20110281894-A1 | HEMIFUMARATE SALT | ASTRAZENECA AB (SE) | 2011-11-17 | — | — | US | disclosed |
| WO-2011142716-A1 | NOVEL HEMIFUMARATE SALT OF ISOINDOLE COMPOUND ACTING AS BACE INHIBITOR | ASTRAZENECA AB (SE) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281894-A1 | HEMIFUMARATE SALT | PSEN1, PSEN2, SNCA | BACE1 5/4885KCNH2 4502/4885BACE2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.