SCHEMBL7701260

SCHEMBL7701260

NC(=NO)c1cc2cc(F)ccc2o1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.43
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
PLAU P00749 1/20 0.40
HDAC1 Q13547 2/20 0.40
HDAC2 Q92769 2/20 0.40
HDAC3 O15379 1/20 0.40
NPC1 O15118 2/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.40
FLT3 P36888 2/20 0.39
CHRM2 P08172 1/20 0.38
CHRM4 P08173 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
PIM1 P11309 2/20 0.37
PIM2 Q9P1W9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7706271 0.98 CHRNA7 (0.42) CHRNA7CA12CA1CA2CA9
SCHEMBL7701256 0.86 NPC1 (0.40) CHRNA7CA12CA9HDAC1HDAC2
Hydrochloric Acid SCHEMBL7709258 0.85 NPC1 (0.39) CHRNA7CA12CA9HDAC1HDAC2
SCHEMBL2704996 0.79 NPC1 (0.49) CHRNA7CA12CA1CA2CA9
SCHEMBL7701265 0.79 CA12 (0.45) CHRNA7CA12CA1CA2CA9
SCHEMBL7701356 0.79 KDM1A (0.31) TSHRFLT3LMNAHPGDMAPT
SCHEMBL24757709 0.78 CA12 (0.39) CHRNA7CA12CA1CA2CA9
SCHEMBL30933144 0.78 CA12 (0.39) CHRNA7CA12CA1CA2CA9
Hydrochloric Acid SCHEMBL7706858 0.77 CA12 (0.44) CHRNA7CA12CA1CA2CA9
SCHEMBL7706872 0.77 FLT3 (0.58) CA12CA1CA9NPC1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906301-B1 BENZOFURYL DERIVATIVES AND THEIR USE HOFFMANN LA ROCHE (CH) 2002-10-02 EP claimed
EP-0906301-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP claimed
WO-1997042183-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1997-11-13 WO claimed
EP-0906301-B1 BENZOFURYL DERIVATIVES AND THEIR USE HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5955495-A BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S HOFFMANN-LA ROCHE INC. (US) 1999-09-21 US disclosed
EP-0906301-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
WO-1997042183-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1997-11-13 WO disclosed