SCHEMBL7701698

SCHEMBL7701698

[CH2]Oc1ccc(OC)cc1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.52
CA1 P00915 2/20 0.52
CA2 P00918 2/20 0.52
CA7 P43166 2/20 0.52
CA9 Q16790 2/20 0.52
CA14 Q9ULX7 2/20 0.52
ALDH1A1 P00352 3/20 0.45
MAPT P10636 3/20 0.45
MEN1 O00255 1/20 0.45
THRB P10828 1/20 0.45
KMT2A Q03164 1/20 0.45
KDM4E B2RXH2 1/20 0.42
GAA P10253 1/20 0.42
ACHE P22303 2/20 0.41
CYP1A2 P05177 3/20 0.41
CYP1A1 P04798 2/20 0.41
CYP1B1 Q16678 2/20 0.41
CYP3A4 P08684 1/20 0.41
IDO1 P14902 2/20 0.40
CYP2A6 P11509 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL82486 0.84 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL1047333 0.80 CA12 (0.74) CA12CA1CA2CA7CA9
SCHEMBL1045996 0.80 CA12 (0.74) CA12CA1CA2CA7CA9
SCHEMBL19011493 0.78 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL740256 0.78 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL8114196 0.78 CA12 (0.52) CA12CA1CA2CA7CA9
SCHEMBL14136161 0.78 CA12 (0.47) CA12CA1CA2CA7CA9
SCHEMBL2092408 0.77 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL958654 0.77 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL12311778 0.75 CA12 (0.48) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6342501-B1 VIRICIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-01-29 US disclosed
WO-2000042043-A1 PYRROLO[2,3-d]PYRIMIDINES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2000-07-20 WO disclosed
EP-0746559-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS The Regents of The University of Michigan (US) 1996-12-11 EP disclosed
US-5543413-A VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1996-08-06 US disclosed
WO-1995023151-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1995-08-31 WO disclosed