Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426655 | 0.94 | MAPK9 (0.66) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2426036 | 0.86 | MAPK9 (0.64) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL1518918 | 0.84 | MAPK9 (0.62) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL6437014 | 0.84 | MAPK9 (0.65) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2428799 | 0.84 | MAPK9 (0.61) | MAPK9MAPK10MEN1KMT2AALDH1A1 | |
| SCHEMBL3479911 | 0.82 | MAPK9 (0.55) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2423811 | 0.82 | MEN1 (0.68) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2420008 | 0.82 | MAPK9 (0.68) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2422442 | 0.82 | MAPK9 (0.65) | MAPK9MAPK10MEN1KMT2ABCL2 | |
| SCHEMBL2425870 | 0.82 | MAPK9 (0.60) | MAPK9MAPK10MEN1KMT2ABCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322642-B1 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of Protein Jun-kinases | MERCK SERONO SA (CH) | 2013-09-04 | — | — | EP | disclosed |
| EP-1193268-A1 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases | Applied Research Systems ARS Holding N.V. (AN) | 2002-04-03 | — | — | EP | disclosed |