Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6135631 | 0.99 | KMT2A (0.33) | KMT2APARP1NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL6134776 | 0.99 | KMT2A (0.33) | KMT2APARP1NPC1RAB9AMEN1 | |
| SCHEMBL7700709 | 0.99 | KMT2A (0.33) | KMT2APARP1NPC1RAB9AMEN1 | |
| SCHEMBL7701255 | 0.91 | KMT2A (0.32) | KMT2APARP1NPC1RAB9AMEN1 | |
| SCHEMBL7696976 | 0.89 | CYP1A2 (0.32) | KMT2APARP1 | |
| SCHEMBL7700272 | 0.89 | TP53 (0.32) | KMT2APARP1MEN1TP53HTT | |
| SCHEMBL7385891 | 0.87 | MAPT (0.33) | KMT2APARP1NPC1RAB9AMEN1 | |
| SCHEMBL7697131 | 0.86 | PARP1 (0.46) | KMT2APARP1NPC1RAB9ATP53 | |
| SCHEMBL7703806 | 0.85 | POLB (0.40) | KMT2ANPC1RAB9AMEN1TP53 | |
| SCHEMBL7700738 | 0.85 | PARP1 (0.37) | KMT2APARP1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346527-B1 | 1-BENZOXEPIN DERIVATIVES USED IN THE PREVENTION OF SODIUM AND HYDROGEN ION EXCHANGE; CARDIOVASCULAR, KIDNEY AND BRAIN DISORDER TREATMENT; ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-12 | — | — | US | claimed |
| EP-1073650-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-07 | — | — | EP | claimed |
| WO-1999055690-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-04 | — | — | WO | claimed |
| EP-1073650-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055690-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-04 | — | — | WO | disclosed |