Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 13/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.54 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | BLK | P51451 | 2/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801783 | 0.92 | AURKB (0.53) | AURKAAURKBIKBKEKDRPDGFRB | |
| SCHEMBL5801797 | 0.85 | AURKA (0.57) | AURKAAURKBIKBKEKDRPDGFRB | |
| SCHEMBL6437239 | 0.84 | KDR (0.66) | AURKAAURKBIKBKEKDRPDGFRB | |
| SCHEMBL6430399 | 0.82 | LCK (0.72) | AURKAAURKBIKBKEKDRTEK | |
| SCHEMBL6430396 | 0.82 | LCK (0.72) | AURKAAURKBIKBKEKDRTEK | |
| SCHEMBL5803692 | 0.81 | KDR (0.62) | AURKAAURKBIKBKEKDRPDGFRB | |
| Acetic Acid SCHEMBL6435211 | 0.81 | LCK (0.71) | AURKAAURKBIKBKEKDRTEK | |
| Acetic Acid SCHEMBL6435206 | 0.81 | LCK (0.71) | AURKAAURKBIKBKEKDRTEK | |
| SCHEMBL6430834 | 0.81 | LCK (0.53) | AURKAAURKBIKBKEKDRPDGFRB | |
| SCHEMBL6431538 | 0.81 | LCK (0.53) | AURKAAURKBIKBKEKDRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156081-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, CYP2D6, UGT1A1 | AURKA 443/4885AURKB 481/4885IKBKE 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.