Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563017 | 0.82 | PDE10A (0.58) | PDE10AALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL2561094 | 0.68 | PDE10A (0.54) | PDE10AALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL2561026 | 0.68 | PDE10A (0.56) | PDE10AALDH1A1KMT2ATSHRHPGD | |
| SCHEMBL2560675 | 0.68 | PDE10A (0.50) | PDE10AALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL2559749 | 0.67 | PDE10A (0.53) | PDE10AMAPTHTTPDE4APDE4B | |
| SCHEMBL2563219 | 0.66 | PDE10A (0.63) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2553598 | 0.66 | PDE10A (0.53) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7711267 | 0.66 | PDE10A (0.59) | PDE10AL3MBTL1TSHRHPGDPDE4A | |
| SCHEMBL2559769 | 0.66 | PDE10A (0.53) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2560597 | 0.65 | PDE10A (0.52) | PDE10AALDH1A1KMT2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |