Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695330 | 0.86 | CA12 (0.46) | CA12CA9KMT2APARP1SMN1; SMN2 | |
| SCHEMBL7696929 | 0.80 | CA12 (0.47) | CA12CA9KMT2APARP1SMN1; SMN2 | |
| SCHEMBL7386387 | 0.80 | CA12 (0.63) | CA12CA9KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7700026 | 0.80 | CA12 (0.43) | CA12CA9KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7700005 | 0.79 | CA12 (0.46) | CA12CA9KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7702855 | 0.79 | CA12 (0.46) | CA12CA9KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7699846 | 0.78 | TSHR (0.46) | CA12CA9KMT2APARP1SMN1; SMN2 | |
| SCHEMBL7701049 | 0.77 | PARP1 (0.35) | KMT2APARP1ALOX5MAPK14 | |
| SCHEMBL7701052 | 0.77 | PARP1 (0.33) | PARP1MAPK14 | |
| SCHEMBL7700010 | 0.77 | CA12 (0.46) | CA12CA9KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346527-B1 | 1-BENZOXEPIN DERIVATIVES USED IN THE PREVENTION OF SODIUM AND HYDROGEN ION EXCHANGE; CARDIOVASCULAR, KIDNEY AND BRAIN DISORDER TREATMENT; ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-12 | — | — | US | disclosed |
| EP-1073650-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055690-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-04 | — | — | WO | disclosed |