Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703527 | 1.00 | RET (0.46) | RETTDP2RPS6KA3CSF1RMAPT | |
| SCHEMBL5432741 | 0.89 | RET (0.46) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5432746 | 0.89 | RET (0.46) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5873980 | 0.89 | RET (0.46) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5422637 | 0.85 | NTRK3 (0.43) | RETTDP2CSF1RMAPTAURKB | |
| SCHEMBL5422639 | 0.85 | NTRK3 (0.43) | RETTDP2CSF1RMAPTAURKB | |
| SCHEMBL5421327 | 0.85 | RET (0.42) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5421335 | 0.85 | RET (0.42) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5873797 | 0.85 | RET (0.42) | RETTDP2RPS6KA3CSF1RPIM1 | |
| SCHEMBL5437889 | 0.83 | PDGFRB (0.46) | RETTDP2CSF1RMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |