Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 13/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.35 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3881959 | 0.82 | CYSLTR2 (0.43) | ERN1CYSLTR2CYSLTR1TLR2TLR1 | |
| SCHEMBL3338705 | 0.79 | TDP1 (0.36) | ERN1CYSLTR2CYSLTR1 | |
| SCHEMBL13563242 | 0.79 | F2RL1 (0.36) | ERN1 | |
| SCHEMBL3337249 | 0.77 | ERN1 (0.51) | ERN1CYSLTR2CYSLTR1TLR2TLR1 | |
| SCHEMBL6230815 | 0.76 | CNR1 (0.39) | — | |
| SCHEMBL14237093 | 0.75 | ERN1 (0.48) | ERN1TLR2TLR1TLR6 | |
| SCHEMBL13924219 | 0.74 | PRKCI (0.44) | — | |
| SCHEMBL3881769 | 0.74 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1 | |
| SCHEMBL454110 | 0.73 | ERN1 (0.72) | ERN1 | |
| SCHEMBL23829701 | 0.72 | HPGD (0.42) | ERN1CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100347164-C | Benzofuryl derivatives and their use | HOFMMANN LA ROCHE AG F (CH) | 2007-11-07 | — | — | CN | disclosed |
| EP-0906301-B1 | BENZOFURYL DERIVATIVES AND THEIR USE | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5955495-A | BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S | HOFFMANN-LA ROCHE INC. (US) | 1999-09-21 | — | — | US | disclosed |
| CN-1217720-A | Benzofuryl derivatives and their use | HOFMMANN LA ROCHE (CH) | 1999-05-26 | — | — | CN | disclosed |
| EP-0906301-A1 | BENZOFURYL DERIVATIVES AND THEIR USE | F. HOFFMANN-LA ROCHE AG (CH) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997042183-A1 | BENZOFURYL DERIVATIVES AND THEIR USE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-13 | — | — | WO | disclosed |