Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.63 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713587 | 0.92 | PDE10A (0.67) | PDE10AGRM2PDE4BPDE4APDE4C | |
| SCHEMBL2556983 | 0.92 | PDE10A (0.54) | PDE10AGRM2PDE4BPDE4APDE4C | |
| SCHEMBL2576417 | 0.88 | PDE10A (0.62) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2561569 | 0.88 | PDE10A (0.59) | PDE10AGRM2PDE4BPDE4APDE4C | |
| SCHEMBL7710971 | 0.87 | PDE10A (0.83) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7711267 | 0.85 | PDE10A (0.59) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2563219 | 0.84 | PDE10A (0.63) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2572379 | 0.84 | PDE10A (0.63) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2563284 | 0.84 | PDE10A (0.56) | PDE10APDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2561026 | 0.82 | PDE10A (0.56) | PDE10APDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |