Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578651 | 0.79 | CMA1 (0.59) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL30885057 | 0.79 | CMA1 (0.59) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL11988473 | 0.77 | RARB (0.52) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL14827606 | 0.76 | HDAC3 (0.44) | RARBRARGKIF11HDAC3HDAC4 | |
| SCHEMBL15577371 | 0.76 | PDK2 (0.50) | PGR | |
| SCHEMBL30377238 | 0.76 | CA9 (0.53) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL3140413 | 0.76 | CA9 (0.53) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL9095526 | 0.76 | RARB (0.55) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL6260606 | 0.76 | AHR (0.59) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL6266255 | 0.76 | RARB (0.51) | RARBRARGHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |