Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704339 | 1.00 | PDE4D (0.77) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7704344 | 1.00 | PDE4D (0.77) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5058868 | 0.88 | PDE4D (0.72) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| Tolafentrine SCHEMBL29992625 | 0.87 | PDE4D (1.00) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| Tolafentrine SCHEMBL8326829 | 0.87 | PDE4D (1.00) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| Tolafentrine SCHEMBL159331 | 0.87 | PDE4D (1.00) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| Tolafentrine SCHEMBL4450984 | 0.87 | PDE4D (1.00) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5036841 | 0.83 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5036837 | 0.83 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5064551 | 0.83 | PDE4D (0.65) | PDE4DLMNAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000035-B1 | SUBSTITUTED 6-PHENYLPHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2002-11-27 | — | — | EP | disclosed |
| US-6121279-A | PHOSPHODIESTERASE INHIBITOR FOR TREATING RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-09-19 | — | — | US | disclosed |