Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8212315 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL9138200 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL65518 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL598762 | 0.96 | FFAR3 (0.54) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL4433464 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL11682870 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL2864460 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL3009304 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL270502 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 | |
| Acetic Acid SCHEMBL6374681 | 0.93 | FFAR3 (0.50) | FFAR3LCKFYNLMNAGABRR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346218-B1 | PLACING WASTE INTO CONTAINER HAVING WATER-PERMEABLE WALL MEMBER FORMING CONCAVITY AND HAVING PERIMETER, PROTECTIVE SURFACE COUPLED TO PERIMETER FOR PREVENTING INJURIES AND SELECTIVE ACCESS, WASHING CONTAINER AND WASTE WITH AGITATION | CRAIG MILUM | 2002-02-12 | — | — | US | disclosed |
| US-6113854-A | TREATMENT OF MEDICAL WASTE THAT ARE NOT DEPENDENT UPON INCINERATION. | MILUM, CRAIG | 2000-09-05 | — | — | US | disclosed |