⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196887 | 0.82 | — | — | |
| Diethanolamine SCHEMBL5843119 | 0.82 | — | — | |
| Diethanolamine SCHEMBL8930798 | 0.82 | TSHR (0.36) | — | |
| Diethanolamine SCHEMBL2324 | 0.82 | — | — | |
| Diethanolamine SCHEMBL5307430 | 0.82 | TSHR (0.36) | — | |
| Diethanolamine SCHEMBL23363665 | 0.82 | TSHR (0.36) | — | |
| SCHEMBL2184621 | 0.81 | — | — | |
| SCHEMBL4026517 | 0.81 | — | — | |
| Diethanolamine SCHEMBL11812460 | 0.79 | — | — | |
| Diethanolamine SCHEMBL8150030 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900637-B1 | THIAZOLE OR IMIDAZOLE SUBSTITUTED PYRIMIDINE, PYRIDINE AND PYRAZINE AMIDE DERIVATIVES AND RELATED COMPOUNDS AS ABL1, ABL2 AND BCR-ABL1 INHIBITORS FOR THE TREATMENT OF CANCER, SPECIFIC VIRAL INFECTIONS AND SPECIFIC CNS DISORDERS | NOVARTIS AG (CH) | 2017-08-09 | — | — | EP | claimed |
| CN-104334529-B | Compounds and compositions for inhibiting the activity of ABL1, ABL2, and BCR-ABL1 | 诺华股份有限公司 | 2017-03-15 | — | — | CN | claimed |
| US-9315489-B2 | Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 | NOVARTIS AG (CH) | 2016-04-19 | — | — | US | claimed |
| EP-2900637-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | Novartis AG (CH) | 2015-08-05 | — | — | EP | claimed |
| US-20150141427-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2015-05-21 | — | — | US | claimed |
| WO-2013171641-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1 | NOVARTIS AG (CH) | 2013-11-21 | — | — | WO | claimed |
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | claimed |
| EP-1780197-B9 | 5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2011-04-06 | — | — | EP | claimed |
| EP-1780197-B1 | 5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2010-10-20 | — | — | EP | claimed |
| US-7745663-B2 | 5-Substituted-2-phenylamino benzamides as MEK inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-06-29 | — | — | US | claimed |
| WO-2010014798-A2 | PYRIMIDOTRIAZINEDIONES AND PYRIMIDOPYRIMIDINEDIONES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-04 | — | — | WO | claimed |
| US-20090233915-A1 | 5-Substituted-2-Phenylamino Benzamides as MEK Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-09-17 | — | — | US | claimed |
| EP-1780197-A1 | 5-SUBSTITUTED-2-PHENYLAMINO-BENZAMIDE AS MEK INHIBITOR | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-05-02 | — | — | EP | claimed |
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | claimed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | claimed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | claimed |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
| EP-3336125-A1 | POLYARYLENE RESIN COMPOSITIONS | Rohm and Haas Electronic Materials LLC (US) | 2018-06-20 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |