SCHEMBL7705897

SCHEMBL7705897

O=C(O)CCCCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 14/20 0.44
MAPT P10636 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
TBXAS1 P24557 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25389429 0.99 MAPT (0.45) SIRT2MAPTRXFP1L3MBTL1TBXAS1
SCHEMBL25389258 0.99 MAPT (0.45) SIRT2MAPTRXFP1L3MBTL1TBXAS1
SCHEMBL25310574 0.99 MAPT (0.45) SIRT2MAPTRXFP1L3MBTL1TBXAS1
SCHEMBL25390529 0.99 MAPT (0.45) SIRT2MAPTRXFP1L3MBTL1TBXAS1
SCHEMBL9263718 0.96 SIRT2 (0.45) SIRT2MAPTRXFP1L3MBTL1TBXAS1
SCHEMBL8448421 0.91 SIRT2 (0.43) SIRT2TBXAS1
SCHEMBL877785 0.90 SIRT2 (0.46) SIRT2
Hydrochloric Acid SCHEMBL8892437 0.89 SIRT2 (0.46) SIRT2
SCHEMBL9521352 0.88 SIRT2 (0.44) SIRT2L3MBTL1
SCHEMBL27569457 0.88 SIRT2 (0.41) SIRT2MAPTRXFP1L3MBTL1TBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161476-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2025-05-22 US disclosed
US-12280124-B2 Antibody-drug conjugates comprising GLP1 peptidomimetics and uses thereof REGENERON PHARMACEUTICALS, INC. (US) 2025-04-22 US disclosed
EP-4489855-A1 ANTI-GLP1R ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF Regeneron Pharmaceuticals, Inc. (US) 2025-01-15 EP disclosed
US-20230330254-A1 ANTI-GLP1R ANTIBODY-TETHERED DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2023-10-19 US disclosed
US-20230330254-A1 ANTI-GLP1R ANTIBODY-TETHERED DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2023-10-19 US disclosed
WO-2023173132-A1 ANTI-GLP1R ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2023-09-14 WO disclosed
CN-116615251-A Antibody-drug conjugates comprising GLP1 peptide mimetics and the uses thereof 瑞泽恩制药公司 2023-08-18 CN disclosed
EP-4210767-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF Regeneron Pharmaceuticals, Inc. (US) 2023-07-19 EP disclosed
US-20220096648-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2022-03-31 US disclosed
WO-2022056494-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF REGENERON PHARMACEUTICALS, INC. (US) 2022-03-17 WO disclosed
CN-1571796-A Melanocortin receptor ligands PROCTER & GAMBLE (US) 2005-01-26 CN disclosed
US-6355665-B1 ANTIHISTAMINES, ANTIALLERGENS AND IRRITABLE BOWEL SYNDROME. JAMES BLACK FOUNDATION LIMITED (GB) 2002-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220096648-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF GLP1R, GIPR, GCGR SIRT2 1935/4885MAPT 2627/4885RXFP1 24/4885
US-20250161476-A1 ANTIBODY-DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF GLP1R, GIPR, GCGR SIRT2 1935/4885MAPT 2627/4885RXFP1 24/4885
US-12280124-B2 Antibody-drug conjugates comprising GLP1 peptidomimetics and uses thereof GLP1R, GIPR, GCGR SIRT2 1935/4885MAPT 2627/4885RXFP1 24/4885
US-20230330254-A1 ANTI-GLP1R ANTIBODY-TETHERED DRUG CONJUGATES COMPRISING GLP1 PEPTIDOMIMETICS AND USES THEREOF GLP1R, GIPR, GCGR SIRT2 1289/4885MAPT 2902/4885RXFP1 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.