SCHEMBL7705898

SCHEMBL7705898

COc1cc(Cc2cnc(N)nc2N)cc(C(=O)/C=C/N2CCc3ccccc3C2c2cc(CN3CCN(C)CC3)n(C)n2)c1OC

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7702365 0.95
SCHEMBL7702930 0.90 SMN1; SMN2 (0.41) SMN1; SMN2
SCHEMBL7699134 0.87 MEN1 (0.45) SMN1; SMN2
SCHEMBL7698069 0.87 MEN1 (0.45) SMN1; SMN2
SCHEMBL7706656 0.86 SMN1; SMN2 (0.48) SMN1; SMN2
SCHEMBL7698318 0.86 SMN1; SMN2 (0.42) SMN1; SMN2
SCHEMBL7703562 0.85 MEN1 (0.43) SMN1; SMN2
SCHEMBL7704158 0.85 SMN1; SMN2 (0.42) SMN1; SMN2
SCHEMBL7706753 0.85 SMN1; SMN2 (0.43) SMN1; SMN2
SCHEMBL7699850 0.85 SMN1; SMN2 (0.43) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901488-B1 2,4-DIAMINOPYRIMIDINE DERIVATIVES BASILEA PHARMACEUTICA AG (CH) 2002-11-06 EP disclosed