Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 13/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1E | P28566 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16454642 | 0.98 | PDE10A (0.47) | PDE10ACHRNB2CHRNA4GABRA1GABRB2 | |
| SCHEMBL7701988 | 0.83 | PDE10A (0.49) | PDE10ACHRNB2CHRNA4HTR3A | |
| SCHEMBL7705174 | 0.83 | PDE10A (0.49) | PDE10ACHRNB2CHRNA4HTR3A | |
| SCHEMBL7698167 | 0.83 | PDE10A (0.50) | PDE10A | |
| SCHEMBL2593698 | 0.83 | PDE10A (0.52) | PDE10ACHRNB2CHRNA4NISCHHTR2A | |
| Hydrochloric Acid SCHEMBL9988661 | 0.82 | PDE10A (0.48) | PDE10ACHRNB2CHRNA4HTR3A | |
| Hydrochloric Acid SCHEMBL9988226 | 0.82 | PDE10A (0.48) | PDE10ACHRNB2CHRNA4HTR3A | |
| SCHEMBL7694260 | 0.81 | PDE10A (0.54) | PDE10ACHRNB2CHRNA4GABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL9988584 | 0.81 | PDE10A (0.51) | PDE10ACHRNB2CHRNA4NISCHHTR2A | |
| Hydrochloric Acid SCHEMBL9988279 | 0.81 | PDE10A (0.49) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143365-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |