Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707927 | 0.87 | GPBAR1 (0.49) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7705517 | 0.85 | GPBAR1 (0.59) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7707344 | 0.82 | GPBAR1 (0.53) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7712708 | 0.80 | GPBAR1 (0.50) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7704262 | 0.80 | GPBAR1 (0.50) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7712828 | 0.78 | PDE10A (0.48) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL7705438 | 0.78 | GPBAR1 (0.47) | GPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL1696038 | 0.75 | GPBAR1 (0.46) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL1696037 | 0.75 | GPBAR1 (0.46) | GPBAR1CYSLTR1CYSLTR2PDE10AFFAR1 | |
| SCHEMBL24951274 | 0.72 | PDE10A (0.56) | GPBAR1CYSLTR1CYSLTR2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138657-A1 | ARYL SUBSTITUTED OLEFINIC COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-11-10 | — | — | WO | disclosed |