Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 12/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 11/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6874983 | 0.95 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL6882136 | 0.93 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7063154 | 0.85 | CHRNA7 (0.38) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7061872 | 0.84 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL6884781 | 0.81 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7063330 | 0.81 | CHRNA7 (0.38) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL6875498 | 0.80 | CHRNA7 (0.42) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL7064115 | 0.80 | CHRNA7 (0.40) | CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL6882726 | 0.80 | ITK (0.46) | CHRNA7 | |
| SCHEMBL6882524 | 0.80 | CHRNA7 (0.47) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486172-B2 | ADMINISTERING TO A MAMMAL A THERAPEUTICALLY EFFECTIVE AMOUNT OF BENZAMIDE OR BENZOCARBONYLSULFIDE SUBSTITUTED 1-AZABICYCLO(2,2,2)OCT-3-YL COMPOUNDS TO TREAT THE CONDITIONS ASSOCIATED WITH DEFECTS OF NICOTINIC SUBTYPES BRAIN RECEPTORS | PHARMACIA & UPJOHN COMPANY | 2002-11-26 | — | — | US | claimed |