Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630936 | 0.85 | PDE10A (0.71) | PDE10A | |
| SCHEMBL7707446 | 0.80 | PDE10A (0.62) | PDE10A | |
| SCHEMBL7705413 | 0.80 | PDE10A (0.50) | PDE10A | |
| SCHEMBL7710220 | 0.76 | PDE10A (0.67) | PDE10A | |
| SCHEMBL7710223 | 0.76 | PDE10A (0.67) | PDE10A | |
| SCHEMBL15134923 | 0.76 | PDE10A (0.67) | PDE10A | |
| SCHEMBL2631158 | 0.76 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2631160 | 0.75 | PDE10A (0.64) | PDE10A | |
| SCHEMBL2630926 | 0.73 | PDE2A (0.66) | PDE10A | |
| SCHEMBL2630895 | 0.72 | PDE10A (0.60) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |