⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13562 | 0.97 | — | — | |
| SCHEMBL28722776 | 0.94 | — | — | |
| Iodide SCHEMBL31112409 | 0.94 | — | — | |
| SCHEMBL28088295 | 0.94 | — | — | |
| Lithium SCHEMBL29523612 | 0.94 | — | — | |
| Bromide SCHEMBL9222450 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL15415090 | 0.94 | — | — | |
| Bromide SCHEMBL9456732 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL3413512 | 0.94 | — | — | |
| Fluoride SCHEMBL28168123 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12448363-B2 | Kinase inhibitors | VIDYA THERAPEUTICS, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| CN-115867346-B | Kinase inhibitors | GB005股份有限公司 | 2025-03-14 | — | — | CN | disclosed |
| US-20230219923-A1 | KINASE INHIBITORS | VIDYA THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| EP-4157446-A1 | KINASE INHIBITORS | GB002, Inc. (US) | 2023-04-05 | — | — | EP | disclosed |
| CN-115867346-A | Kinase inhibitors | GB005股份有限公司 | 2023-03-28 | — | — | CN | disclosed |
| US-20220000856-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2022-01-06 | — | — | US | disclosed |
| US-11071729-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | ADDEX PHARMACEUTICALS S.A. (CH) | 2021-07-27 | — | — | US | disclosed |
| US-20200038391-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2020-02-06 | — | — | US | disclosed |
| US-20150336930-A1 | 1',3'-Disubstituted-4-Phenyl-3,4,5,6-Tetrahydro-2H,1'H-[1,4']Bipyridinyl-2'-Ones | JANSSEN PHARMACEUTICALS INC (US) | 2015-11-26 | — | — | US | disclosed |
| US-9132122-B2 | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′]bipyridinyl-2′-ones | Janssen Pharmaceuticals, Inc. (US) | 2015-09-15 | — | — | US | disclosed |
| EP-1173432-B9 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2008-10-15 | — | — | EP | disclosed |
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| EP-1173432-B1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS ALLELIX CORP (CA) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007099166-A1 | PYRAZOLO-PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |
| EP-1173432-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | NPS Allelix Corp. (CA) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063203-A1 | PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-26 | — | — | WO | disclosed |
| US-6133287-A | SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS, E.G., PSYCHOSIS, SCHIZOPHRENIA, MANIC DEPRESSION, DEPRESSION, MEMORY DISTURBANCES, PARKINSONISM, AMYLOTROPHIC LATERAL SCLEROSIS, ALZHEIMER'S AND HUNTINGTON'S DISEASE | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-10-17 | — | — | US | disclosed |
| US-4788203-A | INHIBITING CALCIUM INDUCED CONTRACTION; USED IN CHEMOTHERAPHY TREATMENT | MERCK & CO., INC. (US) | 1988-11-29 | — | — | US | disclosed |
| US-4721708-A | CYCLICATION WITH LEWIS ACIDS | MERCK & CO., INC. (US) | 1988-01-26 | — | — | US | disclosed |