Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.68 |
| ▸ | PDE2A | O00408 | 2/20 | 0.68 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.68 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15134925 | 0.99 | PDE10A (0.67) | PDE10APDE2APDE1BPDE4DPDE11A | |
| SCHEMBL7705779 | 0.87 | PDE10A (0.69) | PDE10A | |
| Hydrochloric Acid SCHEMBL2630814 | 0.86 | PDE10A (0.68) | PDE10A | |
| SCHEMBL2631048 | 0.83 | PDE10A (0.67) | PDE10APDE2APDE1BPDE4DPDE11A | |
| SCHEMBL7702373 | 0.82 | PDE10A (0.60) | PDE10A | |
| SCHEMBL2631107 | 0.81 | PDE10A (1.00) | PDE10APDE2APDE1BPDE4D | |
| SCHEMBL17874873 | 0.81 | PDE10A (0.65) | PDE10APDE2APDE1BPDE4DPDE11A | |
| Hydrochloric Acid SCHEMBL15134934 | 0.81 | PDE10A (0.59) | PDE10A | |
| SCHEMBL17874872 | 0.80 | PDE10A (0.53) | PDE10APDE2APDE1BPDE4D | |
| Hydrochloric Acid SCHEMBL2630956 | 0.79 | PDE10A (0.52) | PDE10APDE2APDE1BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |