Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711014 | 1.00 | CHRM1 (0.37) | CHRM1CHRNB2CHRNA4CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL15134975 | 0.99 | CHRM1 (0.36) | CHRM1CHRNB2CHRNA4CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL15134977 | 0.99 | CHRM1 (0.36) | CHRM1CHRNB2CHRNA4CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL15134976 | 0.99 | CHRM1 (0.36) | CHRM1CHRNB2CHRNA4CHRM2CHRM3 | |
| SCHEMBL7703924 | 0.82 | PDE10A (0.44) | CHRNB2CHRNA4HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL15134944 | 0.82 | PDE10A (0.44) | CHRNB2CHRNA4HTR1ASLC6A2 | |
| SCHEMBL7704693 | 0.82 | PDE10A (0.44) | CHRNB2CHRNA4HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL15134902 | 0.82 | PDE10A (0.44) | CHRNB2CHRNA4HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL15134903 | 0.82 | PDE10A (0.44) | CHRNB2CHRNA4HTR1ASLC6A2 | |
| SCHEMBL30775438 | 0.76 | IRAK4 (0.44) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |