Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1234977 | 1.00 | SPHK1 (0.52) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL30575899 | 1.00 | SPHK1 (0.52) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL600713 | 1.00 | SPHK1 (0.52) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL27881377 | 1.00 | SPHK1 (0.52) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL28501015 | 0.94 | SPHK1 (0.61) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL258560 | 0.94 | SPHK1 (0.48) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL30787405 | 0.91 | SPHK1 (0.65) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL427800 | 0.91 | SPHK1 (0.46) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL30787346 | 0.91 | SPHK1 (0.65) | SPHK1CYP2D6GMNNLMNAPOLB | |
| SCHEMBL14666494 | 0.91 | SPHK1 (0.65) | SPHK1CYP2D6GMNNLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109336887-B | Benzimidazole chiral heterocyclic compound and preparation method and application thereof | 中山大学 | 2021-12-17 | — | — | CN | claimed |
| CN-106831862-B | Chiral bridged axial chiral monophosphine ligand and preparation method thereof | 中山大学 | 2021-01-15 | — | — | CN | claimed |
| CN-109336887-B | Benzimidazole chiral heterocyclic compound and preparation method and application thereof | 中山大学 | 2021-12-17 | — | — | CN | disclosed |
| CN-106831862-B | Chiral bridged axial chiral monophosphine ligand and preparation method thereof | 中山大学 | 2021-01-15 | — | — | CN | disclosed |
| US-8828902-B2 | Microencapsulated catalyst methods of preparation and method of use thereof | REAXA LIMITED (GB) | 2014-09-09 | — | — | US | disclosed |
| US-8828902-B2 | Microencapsulated catalyst methods of preparation and method of use thereof | REAXA LIMITED (GB) | 2014-09-09 | — | — | US | disclosed |
| US-7662846-B2 | Selective spirocyclic glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-02-16 | — | — | US | disclosed |
| US-7662846-B2 | Selective spirocyclic glucocorticoid receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-02-16 | — | — | US | disclosed |
| EP-1617806-B1 | SELECTIVE SPIROCYCLIC GLUCOCORTICOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2009-11-04 | — | — | EP | disclosed |
| US-6472570-B1 | Method for the asymmetric dihydroxylation of olefins, using osmium catalysts | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-29 | — | — | US | disclosed |