SCHEMBL7709090

SCHEMBL7709090

CSCC[C@H](NC(=O)c1ccc(C=C(Cn2ccnc2)c2ccc(F)cc2)cc1-c1ccc(F)cc1)C(N)=O

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FNTA P49354 11/20 0.44
FNTB P49356 11/20 0.44
CYP51A1 Q16850 2/20 0.39
CYP19A1 P11511 1/20 0.38
PGGT1B P53609 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709086 1.00 FNTA (0.44) FNTAFNTBCYP51A1CYP19A1PGGT1B
SCHEMBL7709321 1.00 FNTA (0.44) FNTAFNTBCYP51A1CYP19A1PGGT1B
SCHEMBL7703293 0.93 FNTA (0.52) FNTAFNTB
SCHEMBL8360606 0.93 FNTA (0.52) FNTAFNTB
SCHEMBL7703301 0.93 FNTA (0.52) FNTAFNTB
SCHEMBL7709025 0.92 FNTA (0.44) FNTAFNTBCYP51A1CYP19A1TDP1
SCHEMBL7706086 0.91 FNTA (0.55) FNTAFNTB
SCHEMBL7706082 0.91 FNTA (0.55) FNTAFNTB
SCHEMBL8223346 0.89 FNTA (0.47) FNTAFNTBCYP51A1
SCHEMBL7703315 0.88 FNTA (0.52) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6414145-B1 TREATING CANCER AND NEUROFIBROMATOSIS ZENECA LIMITED (GB) 2002-07-02 US claimed